GRUP DE RECERCA EN NUTRICIÓ COMUNITÀRIA I ESTRÉS OXIDATIU

Universitat de les Illes Balears (Illes Balears)

Director: Josep Antoni Tur Marí

Adreça mail de contacte del grup de Recerca: nucox@uib.cat

Telèfon de contacte: (+34) 971 17 31 46

Actualització fitxa tècnica del grup: juliol 2017

MEMBRES DEL GRUP INVESTIGADOR

Josep Antoni Tur i Marí; Catedràtic de Fisiologia, Universitat de les Illes Balears (IP del Grup)
a/e: antonipons@uib.es

Antoni Pons Biescas; Catedràtic de Bioquímica i Biologia Molecular, Universitat de les Illes Balears
a/e: antonipons@uib.es

Antoni Sureda Gomila; Professor Titular de Bioquímica i Biologia Molecular, Universitat de les Illes Balears
a/e: antoni.sureda@uib.es

Jordi Pich Solé; Professor Titular de Psicologia Bàsica, Universitat de les Illes Balears
a/e: jpich@uib.es

Maria del Mar Bibiloni Esteva; Professora Contractada Doctor de Fisiologia, Universitat de les Illes Balears
a/e: mar.bibiloni@uib.es

Isabel Llompart Alabern; Professora Associada de Fisiologia & FEA Anàlisis Clíniques, Universitat de les Illes Balears & Hospital Universitari Son Espases, Palma
a/e: isabel.llompart@ssib.es

Joan Miquel Batle Vidal; Professor Associat de Fisiologia & FEA Medicina Hiperbàrica, Universitat de les Illes Balears & Clínica Juaneda, Palma
a/e: jmbatle@medisub.org

Silvia Tejada Gavela; Professora Associada de Fisiologia & Tècnic Superior a Hospital, Universitat de les Illes Balears & Hospital Universitari Son Llàtzer, Palma
a/e: silviatejadagavela@hotmail.com

José Maria Gámez Martínez; Professor Associat de Fisiologia & FEA Cardiologia, Universitat de les Illes Balears & Hospital Universitari Son Llàtzer, Palma
a/e: jmgamez@hsll.es

Tomás Ripoll Vera; FEA Cardiologia, Hospital Universitari Son Llàtzer, Palma
a/e: tripoll@hsll.es

Lucía Ugarriza Hierro; Esp Atenció Primària, IBSalut CS Camp Redó, Palma
a/e: lugarriza@ibsalut.caib.es

Tomás Rodríguez Ruiz; Esp Atenció Primària, IBSalut CS Son Ferriol, Palma
a/e: trodriguez@ibsalut.caib.es

Andrés De la Peña Fernández; FEA Medicina Interna, Hospital Universitari Son Llàtzer, Palma
a/e: adelapen@hsll.es

Alicia Julibert Garcia; Investigadora pre-doctoral contractada, Universitat de les Illes Balears & CIBEROBN
a/e: aliciajulibert@gmail.com

Manuela Abbate; Investigadora pre-doctoral contractada, Universitat de les Illes Balears
a/e: manuela.abbate@uib.es

Laura Gallardo Alfaro; Investigadora pre-doctoral becària FPU, Universitat de les Illes Balears
a/e: lauragala3@gmail.com

Emma Argelich Trigo; Infermera, Hospital de Manacor
a/e: eargelich15@gmail.com

Cristina Bouza Velasco; Investigadora pre-doctoral contractada; Universitat de les Illes Balears & CIBEROBN
a/e: cristinabouvel@gmail.com

David Mateos López; Infermer, Hospital Universitari Son Espases, Palma
a/e: david-mateos@hotmail.com

Alejandra Arenas Puig; Infermera; Hospital Universitari Son Llàtzer, Palma
a/e: alejandraarenaspuig@gmail.com

Xavier Capó Fiol; Investigador postdoctoral contractat, Universitat de les Illes Balears
a/e: xaviercapofiol@gmail.com

Carla Busquets Cortès; Investigadora predoctoral becària FPU, Universitat de les Illes Balears
a/e: carla.busquets.cortes@gmail.com

Sandra Carreres Rey; Investigadora predoctoral becària FPU, Universitat de les Illes Balears
a/e: carreresrey.s@gmail.com

Sofia Montemayor Frias; Investigadora predoctoral becària Rotary Club, Universitat de les Illes Balears
a/e: sofiamf16@gmail.com

Catalina Maria Mascaró Bestard; Investigadora predoctoral, Universitat de les Illes Balears
a/e: catalinamaria95@hotmail.com

ACTIVITATS I CAPACITATS DEL GRUP DE RECERCA

El grup, creat en 2001, és multidisciplinar i interinstitucional, fa part de CIBEROBN (CB12/03/30038), de la RETIC Predimed (RD06/0045/1004), de la xarxa Spanish Exernet de recerca en exercici físic i salut per a poblacions especials i de les Xarxes Europees MEDIS (Nutrition in Mediterranean Islands) i NutriOx (Nutrients and Oxidative Stress) que ha rebut l’Acció COST CA16112. Realitza estudis epidemiològics d’hàbits nutricionals i estils de vida, així com anàlisis d’estrès oxidatiu i mecanismes antioxidants, en estats diversos fisiològics i patològics, i reuneix el grau d’experiència per a dur-ho a terme de forma altament productiva pel que fa a increment del coneixement i en implementació dels resultats i explotació social i econòmica dels resultats. Ha desenvolupat estudis de recerca a Espanya, Grècia, Argentina, Mèxic i Marroc. Des de 2007 és implicat en el Projecte Predimed i des de 2015 en el Projecte PREDIMEDPLUS. És reconegut com a grup de recerca coherent molt competitiu pel Govern de les Illes Balears.

LÍNIES DE RECERCA

Línia: Caracterització i seguiment del patró alimentari de la població, la prevalença d’obesitat i les seves comorbilitats
Investigador principal: Josep Antoni Tur Marí i Maria del Mar Bibiloni Esteva

Línia: Estrès oxidatiu, marcadors d’inflamació i antioxidants.
Investigador principal: Antoni Pons Biescas i Antoni Sureda Gomila

Línia: Estudi longitudinal d’intervenció de l’efecte de la dieta mediterrània sobre la salut cardiovascular
Investigador principal: Josep Antoni Tur Marí

Línia: Avaluació de l’efecte de l’activitat física sobre la qualitat de vida. Antioxidants i rendiment esportiu
Investigador principal: Antoni Pons Biescas i Antoni Sureda Gomila

Línia: Recerca d’estratègies que potenciïn les defenses antioxidants
Investigador principal: Antoni Pons Biescas i Antoni Sureda Gomila

Línia: Estrès oxidatiu, antioxidants i medi ambient
Investigador principal: Antoni Sureda Gomila

MILLORS PUBLICACIONS DEL GRUP (2015-2017)

Sureda, Antoni; Bibiloni, Maria del Mar; Martorell, Miquel; Buil-Cosiales, Pilar; Marti, Amelia; Pons, Antoni; Tur, Josep A.; Angel Martinez-Gonzalez, Miguel; PREDIMED Study Investigators. Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: The PREDIMED study.
Mol Nutr Food Res. 201660: 2654-2664.
PMID: 27600061

SCOPE: This study assessed plasmatic antioxidant capabilities and xanthine oxidase (XOX) activity in metabolic syndrome patients after 5 years intervention with Mediterranean diet (MeDiet) supplemented with extra-virgin olive oil or with nuts or with low-fat diet (the PREDIMED [PREvención con Dieta MEDiterránea] study).
METHODS AND RESULTS: Seventy-five participants were randomly selected. Daily energy and nutrient intake were assessed with a validated 137-item food frequency questionnaire, and adherence to the MeDiet was assessed using a 14-item questionnaire. Catalase, superoxide dismutase (SOD), myeloperoxidase, XOX activities and protein levels, and protein carbonyl derivatives, nitrotyrosine, nitrite and nitrate levels were determined in overnight fasting venous blood samples. The plasma activity and protein levels of SOD and catalase were significantly higher and XOX activity was lower in MeDiet supplemented with extra-virgin olive oil and MeDiet supplemented with nuts than in the control group. Participants in both MeDiet groups showed higher plasma nitrate levels than in the control group. Adherence to the MeDiet showed a positive correlation with SOD and catalase plasma antioxidant activities.
CONCLUSION: A MeDiet enriched with either virgin olive oil or nuts enhances the plasma antioxidant capabilities and decreases XOX activity in patients with the metabolic syndrome but we did not observe changes in myeloperoxidase or markers of oxidative damage.

A Medina-Remon, A Tresserra-Rimbau, A Pons, Tur JA, M Martorell, E Rosa, MA Martínez-González, E Sacanella, MI Covas, D Corella, J Salas-Salvadó, E Gómez-Gracia, V Ruiz-Gutiérrez, J Lapetra, M García-Valdueza, F Arós, GT Sáez, L Serra-Majem, X Pinto, E Vinyoles, R Estruch, RM Lamuela-Raventos, on behalf of the PREDIMED Study Investigators.
Effects of total polyphenol on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial.
Nutr, Metabol, Cardiovasc Dis, 2015;25(1):60-67.
PMID: 25315667
BACKGROUND AND AIM: Hypertension is one of the main cardiovascular risk factors in the elderly. The aims of this work were to evaluate if a one-year intervention with two Mediterranean diets (Med-diet) could decrease blood pressure (BP) due to a high polyphenol consumption, and if the decrease in BP was mediated by plasma nitric oxide (NO) production.
METHODS AND RESULTS: An intervention substudy of 200 participants at high cardiovascular risk was carried out within the PREDIMED trial. They were randomly assigned to a low-fat control diet or to two Med-diets, one supplemented with extra virgin olive oil (Med-EVOO) and the other with nuts (Med-nuts). Anthropometrics and clinical parameters were measured at baseline and after one year of intervention, as well as BP, plasma NO and total polyphenol excretion (TPE) in urine samples. Systolic and diastolic BP decreased significantly after a one-year dietary intervention with Med-EVOO and Med-nuts. These changes were associated with a significant increase in TPE and plasma NO. Additionally, a significant positive correlation was observed between changes in urinary TPE, a biomarker of TP intake, and in plasma NO (Beta = 4.84; 95% CI: 0.57-9.10).
CONCLUSIONS: TPE in spot urine sample was positively correlated with plasma NO in Med-diets supplemented with either EVOO or nuts. The statistically significant increases in plasma NO were associated with a reduction in systolic and diastolic BP levels, adding to the growing evidence that polyphenols might protect the cardiovascular system by improving the endothelial function and enhancing endothelial synthesis of NO.

Bagur MJ, Murcia MA, Jiménez-Monreal AM, Tur JA, Bibiloni MM, Alonso GL, Martínez-Tomé M.
Influence of Diet in Multiple Sclerosis: A Systematic Review.
Adv Nutr. 2017;8(3):463-472.
PMID: 28507011
Abstract: Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria. The reviewed articles assessed the relations between macro- and micronutrient intakes and MS incidence. The patients involved used alternative therapies (homeopathy), protocolized diets that included particular foods (herbal products such as grape seed extract, ginseng, blueberries, green tea, etc.), or dietary supplements such as vitamin D, carnitine, melatonin, or coenzyme Q10. Current studies suggest that high serum concentrations of vitamin D, a potent immunomodulator, may decrease the risk of MS and the risk of relapse and new lesions, while improving brain lesions and timed tandem walking. Experimental evidence suggests that serum vitamin D concentration is lower during MS relapses than in remission and is associated with a greater degree of disability [Expanded Disability Status Scale (EDSS) score >3]. The findings suggest that circulating vitamin D concentrations can be considered a biomarker of MS and supplemental vitamin D can be used therapeutically. Other studies point to a negative correlation between serum vitamin B-12 concentrations and EDSS score. Vitamin B-12 has fundamental roles in central nervous system function, especially in the methionine synthase-mediated conversion of homocysteine to methionine, which is essential for DNA and RNA synthesis. Therefore, vitamin B-12 deficiency may lead to an increase in the concentration of homocysteine. Further research is clearly necessary to determine whether treatment with vitamin B-12 supplements delays MS progression.

Cantero I, Abete I, Babio N, Arós F, Corella D, Estruch R, Fitó M, Hebert JR, Martínez-González MÁ, Pintó X, Portillo MP, Ruiz-Canela M, Shivappa N, Wärnberg J, Gómez-Gracia E, Tur JA, Salas-Salvadó J, Zulet MA, Martínez JA.
Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial.
Clin Nutr. 2017;pii: S0261-5614(17)30238-8.
PMID: 28734553
BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study.
METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated.
RESULTS: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern.
CONCLUSIONS: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.

Bibiloni MDM, González M, Julibert A, Llompart I, Pons A, Tur JA.
Ten-Year Trends (1999-2010) of Adherence to the Mediterranean Diet among the Balearic Islands’ Adult Population.
Nutrients. 2017;9(7): pii: E749.
PMID: 28684703
Objectives: To assess prevailing food patterns, and its association with physical activity and fitness among Spanish older adults.
Methods: Cross-sectional study in Spain, collecting data from a sample (n = 380; 54% female) aged 55-80 years (men) and 60-80 years (women) with no previously documented cardiovascular disease. Body weight, body fat and waist circumference were assessed. Physical activity performed was measured using the Minnesota Leisure-time Physical Activity Questionnaire (LTPA). Physical fitness was assessed using a validated physical fitness test battery. Food consumption was assessed by a validated semi-quantitative food-frequency questionnaire. Factor analysis identified two major dietary food patterns: “Western” (WDP) and “Mediterranean” (MDP) dietary patterns.
Results: Participants in MDP’s fourth quartile were classified in the second (men) and third (men and women) tertile of LTPA. After adjusting for age, body fat, waist-to-height ratio, and METs, in both sexes, a negative significant association was found between 30-s Chair stand and 6-min walking test, a positive significant association was found between 30-m Gait speed and 8-foot Time Up-and-Go (except in men) tests with WDP. The 30-m Gait speed test was negatively associated with MDP in men.
Conclusions: MDP is associated with more time spent on LTPA, and this association was independent of body composition and a fast gait speed in men. WDP is associated with slower gait speed and lower body strength, agility and aerobic endurance. MDP has protective effect on healthy physical fitness, and WDP may be a contributor to frailty.

INSTITUCIONS QUE RECONEIXEN AL GRUP DE RECERCA

– Agència Espanyola de Consum, Seguretat Alimentària i Nutrició (AECOSAN)

– CIBEROBN (Fisiopatologia de l’Obesitat i la Nutrició), Instituto de Salud Carlos III

– Govern de les Illes Balears

– Institut d’Investigació Sanitària de les Illes Balears

– UE-COST

– Xarxa Exernet (activitat física i salut en poblacions especials)

– Xarxa europea MEDIS (Mediterranean Islands)

– Xarxa europea NutriOx (Nutrients and Oxidative Stress)