Des del Centre Català de la Nutrició (CCNIEC) impulsem la divulgació de publicacions cièntifiques. A partir de les publicacions impulsades pel mateix centre i a través de les publicacions derivades dels projectes finançants pel CCNIEC.
Publicacions impulsades pel CCNIEC
Salas-Salvadó J (Editor)
Barcelona: Institut d’Estudis Catalans (Edicions de la Presdiència, Sèrie Major 7)
Any de publicació: 2020
Alimentació i nutrició a Catalunya: Industrials, Productors, i científics
Edició a cura de Jordi Salas-Salvadó, Montserrat Barbany i Abel MarinéData d’edició: 2019
Entitats: Institut d’Estudis Catalans. Associació Catalana de Ciències de l’Alimentació
Institut d’Estudis Catalans. Centre Català de la Nutrició
A cura de Màrius Foz i Sala i Francesc Gonzàlez i Sastre
INSTITUT D’ESTUDIS CATALANS
Abstract: Una anàlisi exhaustiva i rigorosa d’un tema de gran transcendència mèdica, sanitària i social, una publicació de referència per a l’Administració, per a les autoritats sanitàries, per als professionals de les ciències de la salut i per a la població interessada en els problemes de salut.
Estat nutricional de la població de gent gran a Catalunya
García-Lorda P, Salas-Salvadó J, Foz M (editors)
Institut d’Estudis Catalans
Secció de Ciències Biològiques
Centre Català de la Nutrició de l’IEC
Xarxa Temàtica en Nutrició
Publicacions derivades dels projectes finançats pel CCNIEC
Inflammatory markers and metabolic syndrome among adolescents
González M , Bibiloni M del Mar, Pons A, Llompart I, Tur JA
Eur J Clin Nutr. 2012 Oct;66(10):1141-5.
Background/objectives: The alarming increase in obesity worldwide is of concern, owing to the associations of obesity with metabolic syndrome (MetS), which has been associated with a proinflammatory state characterized by elevated plasma concentrations of several markers of inflammation. The aim of this study was to assess levels of inflammatory markers and their association with MetS among adolescents.
Subjects/methods: A random sample of adolescents (n=362, 143 boys and 219 girls, 12-17 years) was interviewed, anthropometrically measured and provided a fasting blood sample. Circulating levels of adiponectin, leptin, tumour necrosis factor-alpha, plasminogen activator inhibitor 1 (PAI-1), interleukin-6 and high-sensitivity C-reactive protein were measured. The association between inflammatory markers and sex, age, body mass index (BMI) status, MetS, physical activity and blood pressure was also calculated.
Results: Adiponectin levels are inversely associated and leptin levels are directly associated with MetS and BMI, but directly with gender (females show higher levels than boys), and PAI-1 levels are directly associated with MetS, among adolescents.
Conclusions: Leptin, adiponectin and PAI-1 may be used as biomarkers to predict MetS among adolescents.
Association between sedentary behaviour and socioeconomic factors, diet and lifestyle among the Balearic Islands adolescents
Bibiloni M del Mar, Pich J, Córdova A, Pons A, Tur JA
BMC Public Health 2012; 12: 718.
Abstract: BACKGROUND: Many different factors influenced food habits and physical activity patterns of adolescents in a complex interactive way. The aim of this study was to assess association between sedentary behaviour and socioeconomic factors, diet and lifestyle among the Balearic Islands adolescents.
METHODS: A cross-sectional survey (n = 1961; 12–17 years old) was carried out. Physical activity was assessed using the International Physical Activity Questionnaire for adolescents (IPAQ-A). Sedentary behaviour was defined as <300 min/week of moderate and vigorous physical activity. Anthropometric measurements, body image, socio-economic and lifestyle determinants, food consumption, and adherence to the Mediterranean diet were assessed. RESULTS: The prevalence of sedentary behaviour was 37.1% (22.0% boys, 50.8% girls). Active boys consumed frequently breakfast cereals and fresh fruit; active girls yogurt, cheese, breakfast cereals, and fresh fruit; and sedentary girls high fat foods and soft drinks. Sedentary behaviour of girls was directly associated to age, and time spent on media screen and homework, and inversely related to adherence to Mediterranean diet, and body composition. Sedentary behaviour of boys was inversely related to adherence to the Mediterranean diet, and the desire to remain the same weight. CONCLUSIONS: The prevalence of sedentary behaviour among Balearic Islands adolescents is high, mainly among girls. Age, sex, parental educational and profession levels, body size dissatisfaction, and poor quality diet are important factors of physical activity practice among adolescents.
Combined effects of oral oleoyl-estrone and limited food intake on body composition of young overweight male rats
Romero MM, Esteve M, Alemany M
Int J Obes (Lond). 2006 Jul;30(7):1149-56.
Abstract: OBJECTIVE: The combined effects of limited food intake and OE treatment have been analysed in order to determine whether hypocaloric diets enhance the slimming effects of OE on mature overweight male rats. Two levels of dietary limitation at 50 and 25% of a standard intake were established, roughly corresponding to the human LCDs and VLCDs.
DESIGN: Wistar male rats (6 weeks old) were made overweight by a cafeteria diet. After transition to standard diet, they were subjected to food restriction: down to 50 or 25% with respect to the transition period. Half the animals were given daily oral gavages of 10 nmol/g oleoyl-estrone (OE), and the rest received only the vehicle during 10 days.
MEASUREMENTS: Changes in weight and body composition: water, lipid, protein or gross energy were determined by comparing the final pool size with that of day 0, calculated from the initial body weight and the composition of untreated rats. Energy and nitrogen balances were estimated. Plasma levels of metabolites and hormones were also measured.
RESULTS: OE induced changes in body composition similar to those elicited by a 50% reduction in food, with massive loss of lipid and energy. OE-treated rats ate less than the controls, but additional effects on body composition on reduced diet were minimal. OE improved metabolic homoeostasis: better maintained glycaemia, lower cholesterol and shallower hormonal changes, but at the expense of slightly increased protein mobilisation.
CONCLUSIONS: The data presented suggest that no advantages are accomplished by combining OE treatment and hypocaloric diets compared with OE alone, at least under the experimental conditions tested, since the effects were not additive. Despite OE affecting food intake, mechanisms other than that are deemed responsible for the mobilisation of body fat, since intake alone cannot explain the effects on body weight, nor the metabolic and hormonal changes in OE-treated rats. It is concluded that the combination of food restriction and OE may result in unwanted increased protein mobilisation with no synergy between both slimming treatments.
Oleoyl-estrone treatment activates apoptotic mechanisms in white adipose tissue
Salas A, Remesar X, Esteve M
Abstract: To determine whether lipid mobilization in white adipose tissue caused by oleoyl-estrone (OE) treatment leads to activation of apoptosis, female Wistar rats were given a daily oral gavage of 10 micromol/kg of OE in 0.2 ml of sunflower oil and DNA fragmentation in different adipose tissues was assessed by ligation-mediated PCR after 6, 24, 48, or 240 h. Expression of selected apoptotic target genes was analysed by RT-PCR in adipose tissue from animals treated for 2 days. The response of adipose tissue to OE treatment was not the same in all locations. In mesenteric adipose tissue, a significant increase in the expression of Bid, Bax, caspase 3 and caspase 8 was detected, whereas in periovaric adipose tissue, only Bax and caspase 3 expression showed significant increases. No effect was detected in subcutaneous or retroperitoneal adipose tissue. The increased expression of apoptotic factors suggests that this pathway could be activated by OE treatment.
Plasma adiponectin distribution in a Mediterranean population and its association with cardiovascular risk factors and metabolic syndrome
Salas-Salvadó J, Granada M, Bulló M, Corominas A, Casas P, Foz M
Metabolism. 2007 Nov;56(11):1486-92.
Abstract: Adiponectin may play an important role in the regulation of body weight, insulin resistance, and cardiovascular disease. The aim of this study was to evaluate the distribution of adiponectin in a Mediterranean adult population and its relationship with cardiovascular risk factors and metabolic syndrome. A cross-sectional study was performed in a representative sample of 1023 subjects from a Spanish Mediterranean population. Individuals with the metabolic syndrome were identified using the diagnostic criteria of the Adult Treatment Panel III. Anthropometric parameters were measured, and biochemical analyses were performed in fasting conditions. Plasma insulin levels were measured and homeostasis model assessment of insulin resistance was calculated. Plasma adiponectin levels were measured by a commercial radioimmunoassay. Median levels of adiponectin were significantly higher in women than in men after adjusting for differences in body mass index. However, no differences in adiponectin plasma levels were observed in relation to age. Significantly lower levels of adiponectin were also observed in women with obesity, abdominal obesity, hyperglycemia or diabetes, low high-density lipoprotein cholesterol, hypertriglyceridemia, or metabolic syndrome. In men, only those with obesity, abdominal obesity, low high-density lipoprotein cholesterol, hypertriglyceridemia, or metabolic syndrome showed significantly lower plasma levels of adiponectin. In a stepwise multivariate analysis, sex, waist circumference, serum C-reactive protein serum levels, and homeostasis model assessment of insulin resistance explained 23.4% of its variability. In conclusion, adiponectin plasma levels are more closely related to the components of the metabolic syndrome in women than in men in a Mediterranean population.
Treatment of pregnant rats with oleoyl-estrone slows down pup fat deposition after weaning
García-Peláez B, Vilà R, Remesar X.
Reprod Biol Endocrinol. 2008 Jun 20;6:23.
Abstract: BACKGROUND: In rats, oral oleoyl-estrone (OE) decreases food intake and body lipid content. The aim of this study was to determine whether OE treatment affects the energy metabolism of pregnant rats and eventually, of their pups; i.e. changes in normal growth patterns and the onset of obesity after weaning. METHODS: Pregnant Wistar rats were treated with daily intragastric gavages of OE in 0.2 ml sunflower oil from days 11 to 21 of pregnancy (i.e. 10 nmol oleoyl-estrone/g/day). Control animals received only the vehicle. Plasma and hormone metabolites were determined together with variations in cellularity of adipose tissue. RESULTS: Treatment decreased food intake and lowered weight gain during late pregnancy, mainly because of reduced adipose tissue accumulation in different sites. OE-treated pregnant rats’ metabolic pattern after delivery was similar to that of controls. Neonates from OE-treated rats weighed the same as those from controls. They also maintained the same growth rate up to weaning, but pups from OE-treated rats slowed their growth rate afterwards, despite only limited differences in metabolite concentrations. CONCLUSION: The OE influences on pup growth can be partially buffered by maternal lipid mobilization during the second half of pregnancy. This maternal metabolic”imprinting” may condition the eventual accumulation of adipose tissue after weaning, and its effects can affect the regulation of body weight up to adulthood.