GRUP DE RECERCA NUTRICIÓ, ALIMENTACIÓ, CREIXEMENT I SALUT MENTAL – NUTCRSM

Facultat de Medicina de Reus, Universitat Rovira i Virgili (Reus)

Director: Jordi Salas-Salvadó, Catedràtic de Nutrició i Bramatologia, Universitat Rovira i Virgili

Actualització fitxa tècnica del grup: juliol 2017

carles.munne@urv.cat

(+34) 977 75 93 13

(+34) 977 75 93 22

MEMBRES DEL GRUP INVESTIGADOR

Prof. Jordi Salas-Salvadó. Investigador principal. Catedràtic d’Universitat, Unitat de Nutrició Humana. Departament de Bioquímica i Biotecnologia. Universitat Rovira i Virgili. a/e: jordi.salas@urv.cat

Dra. Mònica Bulló Bonet. Co-Investigador principal. Professor Agregat, Unitat de Nutrició Humana. Departament de Bioquímica i Biotecnologia. Universitat Rovira i Virgili. a/e: monica.bullo@urv.cat

Investigadors Postdoctorals

Prof. Joan Fernández Ballart. Catedràtic d’Universitat, Departament de Ciències Mèdiques Bàsiques. Universitat Rovira i Virgili. a/e: joan.fernandez-ballart@urv.cat

Dra. Michelle Murphy. Professor Agregat, Departament de Ciències Mèdiques Bàsiques. Universitat Rovira i Virgili. a/e: michelle.muprhy@urv.cat

Dra. Nancy Babio Sánchez. Professor Agregat, Unitat de Nutrició Humana. Departament de Bioquímica i Biotecnologia. Universitat Rovira i Virgili. a/e: nancy.babio@urv.cat

Dr. Albert Salas-Huetos. Contractat Postdoctoral – IISPV, Unitat de Nutrició Humana. a/e: albert.salas@iispv.cat

Dr. Andrés Díaz López. Contractat Postdoctoral – CIBEROBN, Unitat de Nutrició Humana. a/e: andres.diaz@iispv.cat

Dr. Pablo Hernández Alonso. Contractat Postdoctoral – URV. Unitat de Nutrició Humana. a/e: pablo1280@gmail.com

Dra. Silvia Canudas Puig. Contractada Posdoctoral – Ramón y Cajal, Ministrio de Educación, Cultura y Deporte (MECD) – IISPV. Unitat de Nutrició Humana. a/e: silvia.canudas@iispv.cat

Dr. Cristopher Papandreou. Contractat Postdoctoral – Peris, Generalitat de Catalunya – IISPV. Unitat de Nutrició Humana. a/e: papchris10@gmail.com

Dr. Josep Basora Gallisà, Professor Associat, Universitat Rovira i Virgili. Responsable de Formació i Recerca (Tarragona/Reus), ICS. a/e: jbasora.tarte.ics@gencat.cat

 

Investigadors Predoctorals

Núria Rosique-Esteban. Becari predoctoral AGAUR, Generalitat de Catalunya. Unitat de Nutrició Humana. a/e: nuria.rosique@urv.cat

Nerea Becerra-Tomás. Becari predoctoral. Universitat Rovira i Virgili – Martí Franqués. Unitat de Nutrició Humana. a/e: nerea.becerra@urv.cat

Simona Giardina. Becari predoctoral – Universitat Rovira i Virgili. Unitat de Nutrició Humana. a/e: smn.giardina@gmail.com

Jesús Francisco García-Gavilán. Becari predoctoral – Universitat Rovira i Virgili. Unitat de Nutrició Humana. a/e: jesusfrancisco.garcia@urv.cat

Lucia Camacho-Barcia. Becari predoctoral AGAUR, Generalitat de Catalunya. Unitat de Nutrició Humana. a/e: marialucia.camacho@urv.cat

Guillermo Mena-Sánchez. Becari predoctoral – IISPV. Unitat de Nutrició Humana. a/e: guillermo_menasanchez@hotmail.com

Laura Barrubés Piñol. Becari predoctoral – IISPV. Unitat de Nutrició Humana. a/e: laura.barrubes@estudiants.urv.cat

Gemma Ornosa Martín. Becari predoctoral – Universitat Rovira i Virgili. a/e: gemma.ornosa@urv.cat

Júlia Haro Barceló. Becari predoctoral – IISPV. Unitat de Nutrició Humana. a/e: julia.haro@iispv.cat

Personal Tècnic Contractat

Glòria Mestres-Pedret. Personal Tècnic – CIBEROBN. Unitat de Nutrició Humana. a/e: gloria.mestres89@gmail.com

Rocío Moraleda Castillo. Personal Tècnic – IISPV, Plan Empleo Juvenil. Unitat de Nutrició Humana. a/e: rocio.mc92@gmail.com

Marta Gil Segura. Personal Tècnic – URV, Plan Empleo Juvenil. . Unitat de Nutrició Humana. a/e: marta.gilsegura@gmail.com

Samhira Shig. Personal Tècnic – URV, Plan Empleo Juvenil. Unitat de Nutrició Humana. a/e: samhira.shig@gmail.com

Personal Tècnic de Gestió Administrativa

Carles MUNNE-CUEVAS. PSR – Universitat Rovira i Virgili. Unitat de Nutrició Humana. a/e: carles.munne@urv.cat

Susana SEGURA BENIGNO. Contractada IISPV. Unitat de Nutrició Humana. a/e: susana.segura@iispv.cat

Personal Col·laborador en tasques docents i de recerca:

Dr. Anna Maria Bonada Sanjaume; Dr. Antoni Rabassa Soler; Dr. Rafel Balanzà Roure; Dra. Núria Ibarrola Jurado; Sra. Clara Alegret Basora; Dra. Isabel Megias Rangil; Sra. Núria Guillén Rey; Sra. Núria Gil Segura; Dra. Montserrat Olona Cabases; Dr. Graciano García Pardo;  Dr. Joan Miquel Carbonell Riera; Dr. Joan Guix Oliver; Dr. Pol Solé Navais; Sra Mireia García-Villarrubia; Sr. Arnau Besora Cunillera; Sr. Antoni Foz Bosch; Sr. Josep María Sabaté Guasch; Sra. Marta Herrero Casado; Sra. Maria Pascual; Sra. Rosa Albadalejo

(Actualització de l’apartat: 31/07/2017)

ACTIVITATS I CAPACITATS DEL GRUP DE RECERCA

El Grup de Recerca en Alimentació, Nutrició, Creixement i Salut Mental es un grup amb una trajectòria conjunta des de fa ja més de 25 anys. De fet, des de l’any 1997 el grup es un grup reconegut dins l’estructura d’Unitats de Recerca de la Universitat Rovira i Virgili. Forma part, com a Grup de Recerca, de l’Institut d’Investigació Sanitària Pere Virgili (IISPV). El grup de Recerca forma part del CIBERobn –Fisiopatología de la Nutrición y Obesidad finançat per l’Instituto de Salud Carlos III.

Els objectius del Grup és poden resumir en: 1) Estudiar els determinants clàssics, nutricionals i bioquímics de la incidència de diabetis tipus 2 y la síndrome metabòlica en la cohort de l’estudi PREDIMED; 2) Avaluar l’efecte del consum de fruits secs sobre la inflamació i el metabolisme de la glucosa; 3) Coordinació de l’estudi multicèntric PREDIMED-plus arreu de l’Estat Espanyol en pacients amb sobrepès/obesitat i síndrome metabòlica; 4) Avaluar l’efecte de la càrrega glucèmia de la dieta sobre l’adipositat, la inflamació i la resistència a la insulina així com els mecanismes tissulars implicats; 5) Estudiar la prevalença de la síndrome metabòlica a l’Amèrica Llatina i els seus determinants ambientals; 6) Avaluar l’efecte de la sacietat sobre la pèrdua i el manteniment del pes corporal; 7) Investigar les interaccions entre els folats, vitamines del grup B i gens implicats en el metabolisme monocarbonat sobre la regulació del metabolisme dels folats, cobalamina i homocisteïna (“Folate-mediated one carbon metbolism”); 8) Estudiar la relació entre el metabolisme monocarbonat prenatal i la programació de salut i desenvolupament del nen; 9) Investigar les interaccions entre els folats, vitamines del grup B i gens implicats en el metabolisme monocarbonat sobre la regulació de la xarxa metabòlica i la regulació epigenètica de gens implicats en salut i desenvolupament i 10) Investigar la relació entre les interaccions nutrient-genètics maternes i paternes sobre la funció placentària i l’evolució de l’embaràs.

LÍNIES DE RECERCA

Estudis d’intervenció per a conèixer l’efecte de la dieta o dels constituents de la dieta sobre la salut o la malaltia i els mecanismes implicats.

Estudi de la relació entre l’obesitat, la inflamació y les diferents comorbilitats associades a l’obesitat.

Estudi del metabolisme energètic en l’obesitat.

Efecte de la dieta sobre el metabolisme mitjamçant tècniques òmiques (metabolòmica, trasnscriptòmica i metagenòmica)

Efecte de les interaccions de la genètica i la nutrició sobre la salut en la població.

Identificació de nous biomarcadors per a identificar estratègies de prevenció primària i secundària de malalties cróniques.

Paper de les interaccions nutrient-gen-metabòlic en la programació intrauterina del desenvolupament i salut infantil.

Epidemiologia i salut pública en relació a la nutrició o a les malalties de la nutrició.

MILLORS PUBLICACIONS DEL GRUP (DARRERS 5 ANYS)

  • Bulló M, Amigó-Correig P, Márquez-Sandoval F, Babio N, Martínez-González MA, Estruch R, Basora J, Solà R, Salas-Salvadó J.
    Mediterranean diet and high dietary acid load associated with mixed nuts: effect on bone metabolism in elderly subjects. 
    J Am Geriatr Soc. 2009 Oct;57(10):1789-98.
    PubMed PMID: 19807791.

Objectives: To analyze the effect of differing diet on the acid load content on bone metabolism. DESIGN: Multicentric, randomized, single-blind, parallel-group clinical trial. SETTING: Outpatient clinics. PARTICIPANTS: Two hundred thirty-eight elderly men and women aged 60 to 80 at high risk for cardiovascular disease were randomly assigned to three interventional groups: a recommended low-fat diet (control diet group), a Mediterranean diet supplemented with virgin olive oil, or a Mediterranean diet supplemented with mixed nuts. MEASUREMENTS: Main outcomes were 12-month changes from baseline in bone formation and resorption markers and bone mass measured according to quantitative ultrasound scanning. RESULTS: The baseline data on the anthropometric, bone densitometry, and biochemical variables did not differ between the three groups. Dietary potential renal acid load (PRAL) and daily net endogenous acid production (NEAP) at baseline did not differ between groups. After intervention, subjects allocated to the Mediterranean diet with mixed nuts had a significant increase of PRAL and NEAP. In comparison, subjects in the Mediterranean diet with nuts group had higher parathyroid hormone (PTH) levels (2.63, 95% confidence interval (CI)=-1.01-6.35, P=.02) and a nonsignificantly higher (0.31, 95% CI=-0.13-0.74, P=.14) urine free deoxypyridoxine:creatinine ratio, a marker of bone resorption, than the control group and the Mediterranean diet with virgin olive oil group. CONCLUSION: A Mediterranean dietary pattern associated with a high dietary acid load derived from consumption of mixed nuts does not seem to have a much greater effect on bone metabolism biomarkers, with the exception of PTH levels, than a Mediterranean diet without mixed nuts or a control diet in elderly subjects.

  • Berrocal-Zaragoza MI, Fernandez-Ballart JD, Murphy MM, Cavallé-Busquets P, Sequeira JM, Quadros EV.
    Association between blocking folate receptor autoantibodies and subfertility. 
    Fertil Steril. 2009 Apr;91(4 Suppl):1518-21.
    PubMed PMID: 18950755

Background: The association between blocking folate receptor (FR) autoantibodies and subfertility was investigated in a longitudinal study of women attempting to become pregnant. Seventeen women with subfertility (failure to conceive during 12 menstrual cycles) and 25 control women (women who conceived and went on to have normal pregnancy outcomes) were studied. Subfertility risk was 12 times higher in women with blocking FR autoantibodies compared with those without (odds ratio, 12; 95% confidence interval, 1.9-129.6).

  • Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M, Estruch R, Corella D, Fiol M, Gómez-Gracia E, Arós F, Flores G, Lapetra J, Lamuela-Raventós R, Ruiz-Gutiérrez V, Bulló M, Basora J, Covas MI; PREDIMED Study Investigators.
    Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial.  
    Arch Intern Med. 2008 Dec 8;168(22):2449-58.
    PubMed PMID: 19064829.

Background: Epidemiological studies suggest that the Mediterranean diet (MedDiet) may reduce the risk of developing the metabolic syndrome (MetS). We compared the 1-year effect of 2 behavioral interventions to implement the MedDiet vs advice on a low-fat diet on MetS status. METHODS: A total of 1224 participants were recruited from the PREDIMED (Prevención con Dieta Mediterránea) Study, a multicenter, 3-arm, randomized clinical trial to determine the efficacy of the MedDiet on the primary prevention of cardiovascular disease. Participants were older subjects at high risk for cardiovascular disease. Interventions were quarterly education about the MedDiet plus provision of either 1 L/wk of virgin olive oil (MedDiet + VOO) or 30 g/d of mixed nuts (MedDiet + nuts), and advice on a low-fat diet (control diet). All diets were ad libitum, and there was no increase in physical activity for any of the interventions. Lifestyle variables and MetS features as defined by the National Cholesterol Education Program Adult Treatment Panel III criteria were assessed. RESULTS: At baseline, 61.4% of participants met criteria for the MetS. One-year prevalence was reduced by 6.7%, 13.7%, and 2.0% in the MedDiet + VOO, MedDiet + nuts, and control diet groups, respectively (MedDiet + nuts vs control groups, P = .01; MedDiet + VOO vs control group, P = .18). Incident rates of the MetS were not significantly different among groups (22.9%, 17.9%, and 23.4%, respectively). After adjustment for sex, age, baseline obesity status, and weight changes, the odds ratios for reversion of MetS were 1.3 (95% confidence interval, 0.8-2.1) for the MedDiet + VOO group and 1.7 (1.1-2.6) for the MedDiet + nuts group compared with the control diet group. CONCLUSION: A traditional MedDiet enriched with nuts could be a useful tool in the management of the MetS.

  • Castillejo G, Bulló M, Anguera A, Escribano J, Salas-Salvadó J.
    A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients. 
    Pediatrics. 2006 Sep;118(3):e641-8.
    PubMed PMID: 16950955.

Objective: Although a diet that is rich in fiber is widely recommended for preventing and treating constipation, the efficacy of fiber supplements have not been tested sufficiently in children. Our aim with this pilot study was to
evaluate if fiber supplementation is beneficial for the treatment of children with idiopathic chronic constipation. METHODS: Using a parallel, randomized, double-blind, controlled trial, we conducted an interventional study to evaluate the efficacy of a supplement of cocoa husk rich in dietary fiber on intestinal transit time and other indices of constipation in children with constipation. After screening, the patients were randomly allocated to receive, for a period of 4 weeks, either a cocoa husk supplement or placebo plus standardized toilet training procedures. Before and after 4 weeks of treatment, we (1) performed anthropometry, a physical examination, and routine laboratory measurements, (2) determined total and segmental colonic transit time, (3) evaluated bowel movement habits and stool consistency using a diary, and (4) received a subjective evaluation from the parents regarding the efficacy of the treatment. The main variable for verifying the efficacy of the treatment was the total colonic transit time. RESULTS: Fifty-six chronically constipated children were randomly assigned into the study, but only 48 children completed it. These children, who were aged between 3 and 10 years, had a diagnosis of chronic idiopathic constipation. With respect to total, partial colon, and rectum transit time, there seemed to be a trend, although statistically nonsignificant, toward faster transit times in the cocoa husk group than in the placebo group. When we analyzed the evolution of the intestinal transit time throughout the study of children whose total basal intestinal transit time was > 50th percentile, significant differences were observed between the groups. The total transit time decreased by 45.4 +/- 38.4 hours in the cocoa husk group and by 8.7 +/- 28.9 hours in the placebo group (-38.1 hours). In the case of the right colon, changes in transit time also were significant between groups. Mean changes tended toward faster transit times in the left colon and the rectum, although the differences were not statistically significant. The children who received cocoa husk supplements tended to increase the number of bowel movements by more than that of the children of the placebo group. We also observed a reduction in the percentage of patients who reported hard stools (hard scybalous or pebble-like stools), although this reduction was significantly greater in the cocoa husk group. At the end of the intervention, 41.7% and 75.0% of the patients who received cocoa husk supplementation or placebo, respectively, reported having hard stools. Moreover, a significantly higher number of children (or their parents) reported a subjective improvement in stool consistency. No significant adverse effects were reported during the study. CONCLUSIONS: This study confirms the beneficial effect of a supplement of cocoa husk that is rich in dietary fiber on chronic idiopathic constipation in children. These benefits seem to be more evident in pediatric constipated patients with slow colonic transit time.

  • Salas-Salvadó J, Bulló M, García-Lorda P, Figueredo R, Del Castillo D, Bonada A, Balanzà R.
    Subcutaneous adipose tissue cytokine production is not responsible for the restoration of systemic inflammation markers during weight loss. 
    Int J Obes (Lond). 2006 Dec;30(12):1714-20.
    PMID: 16652132.

Context: It has been suggested that weight loss can improve systemic inflammation associated with obesity by decreasing the adipose production of pro-inflammatory cytokines. This suggestion, however, remains controversial.
OBJECTIVE: To analyse the effect of weight loss on peripheral inflammatory markers and subcutaneous adipocytokine production. DESIGN: Patients were studied at baseline, at the end of the weight loss period, and after 2 weeks of weight stabilisation. SUBJECTS: Nineteen morbid obese non-diabetic patients and 20 lean control
subjects. INTERVENTION: During the weight loss period patients followed a 6-week low-calorie diet. MEASUREMENTS: Plasma levels of inflammatory markers, maximal in vitro whole-blood cytokine production, subcutaneous adipose tissue expression and content of several cytokines. RESULTS: Obese subjects had higher circulating levels of C reactive protein (CRP), serum amyloid A (SAA), interleukin IL-6, IL-1 and soluble tumor necrosis factor receptors (sTNFR). Weight loss was associated with a significant decrease in CRP, SAA, leucocytes and plasma IL-6. Maximal in vitro cytokine production of IL-1 and sTNFR1 increased during this period. Weight loss did not induce significant changes in the adipose concentrations of IL-6, IL-1 or sTNF-receptors. However, adipose expression of IL-6, IL-1, TNFalpha, membrane cofactor protein-1 and adiponectin increased at the end of the weight loss period. During weight maintenance, circulating inflammatory parameters increased and in some cases returned to baseline. CONCLUSIONS: A low-calorie diet is associated with an improvement in the systemic inflammatory status. This seems to be due to energy restriction rather than to adipose mass loss, since inflammatory levels return to baseline soon after weight stabilisation. Furthermore, a negative energy balance and fat mobilisation are associated with increased subcutaneous cytokine adipose expression.

INSTITUCIONS QUE RECONEIXEN AL GRUP DE RECERCA

Universitat Rovira i Virgili

Instituto de Salud Carlos III

CIBER Fisiopatologia de la Obesidad y Nutrición (CB207/03/2004)

Grup de Recerca Consolidat de la Generalitat de Catalunya (2014-SGR-332)

Institut d’Invesitigació Sanitària Pere Virgili